Preheat your oven to 350° F. Spray a 9- x 5-inch loaf pan with nonstick spray.

In a large mixing bowl, combine the barley, herbs, salt, garlic powder, onion powder, oregano, pepper, red pepper flakes, ¼ cup ketchup, and egg. Mix well.

Add meat to the barley mixture. Using a fork or your fingers, mix just until combined, being careful not to compact the meat.

Spoon meat mixture into prepared pan. Spread remaining ¼ cup ketchup over top of loaf.

Bake for 50 to 60 minutes, or until the meatloaf reaches an internal temperature of 165°F on an instant-read thermometer.